Managing and linking groups to users and managed systems

I’m not sure how other admins managed their Password Safe but would love to know how others did theirs.

My main question is that I have thousands of servers with hundreds of different AD groups (privileged Admin accounts) having local admins to several mixed servers. These AD groups were either assigned via GPO or were manually added as local admins to some servers. How do you manage and link these privileged accounts to the managed systems without creating hundreds of different smart rules? Or is there a simpler way to do this?